Articles in Category: More News

Pegylated Substances from 4 to 60 kDa in plasma, CSF and formulation

News from Wednesday, 11 July 2018.

Pegylated Substances from 4 to 60 kDa in plasma, CSF and formulation

pharm-analyt − Leading Lab in PEG Analysis

After having completed another method establishment for a Polyethylenglycol (PEG) recently, pharm-analyt continues to be a leading lab in PEG analysis. Quantitative analysis has always been the main pillar for pharm-analyt for over
3 decades of operation.

Starting in 1986 with bioanalysis and HPLC-UV nowadays GMP release analysis and HPLC-MS/MS are at the core of pharm-analyt's activities. With only 20 people being employed at pharm-analyt we have kept our flexibility in order to solve analytical challenges and more recently also consistently keep timelines.

Quantifying PEGylated substances has been a specialty for more than a decade becoming a core competence in the last 2 years. At the moment pharm-analyt serves 4 different clients with quantitative analysis of PEGs and has methods to determine altogether 6 current pegylated substances in the range of 4 to 60 kDa.

pharm-analyt has covered PEG determination in the biological matrices rat/human plasma/CSF and FDP/FC/BDS formulations, always going in the direction of using stable labelled internal standards.

The most refined and up-to-date method has a calibration range of 20 to 1,000 ng/mL for a more than 30 kDa PEG in plasma with a calibration curve that is linear.

We are good at analysing various peptides, mycotoxins and anthracyclines which makes us a valued provider for the pharmaceutical industry especially in oncology/chemotherapy. However, amazement you would only experience with the PEG analytical competence and metaknowledge you will find at pharm-analyt.

Send us your quantitative analytical problem with a PEG over, you will have a 95 % chance that we will have a solution within short time.

 

> 30 kDa Free PEG in Plasma
Calibration range 20.0 – 1,000 ng/mL
Upper chrom Std at LLOQ
Lower chrom internal standard
HPLC-MS/MS

Meet our Founder @ Rare 2018 in London

News from Wednesday, 21 March 2018.

Meet our Founder @ Rare 2018 in London

Meet our Founder @ Rare 2018 in London

Meet our Founder at Rare 2018 in London!

Hermann is well known in the community, as he found several biomarkers for rare lysosomal diseases e.g. Fabry, Gaucher, NP-C, MLD.